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1.  Increased Time Indoors = Increased Exposure.  People spend a considerable amount of time indoors.  As a result, exposure to indoor contaminants is of great concern, notably … for infants and toddlers. http://www.annualreviews.org/doi/abs/10.1146/annurev.pu.04.050183.001223?journalCode=publhealth Health Effects of Indoor Pollutants Annual Review of Public Health Vol. 4: 203-221 (Volume publication date May 1983)  DOI: 10.1146/annurev.pu.04.050183.001223 

2. Risk to Men?  Fipronil … inhibits testosterone metabolismhttp://pubs.acs.org/doi/abs/10.1021/bk-2012-1099.ch008?prevSearch=fipronil%2Btestosterone&searchHistoryKey=  Ernest Hodgson*, Andrew D. Wallace* Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695 Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment Chapter 8, pp 115–132 Chapter DOI: 10.1021/bk-2012-1099.ch008 ACS Symposium Series, Vol. 1099 ISBN13: 9780841226456eISBN: 9780841226463 Publication Date (Web): July 25, 2012 Copyright © 2012 American Chemical Society 

3. Pesticides Measured from Floor Wipes U.S. Dept. of Housing and Urban Development study in collaboration with … E.P.A. conducted a survey measuring insecticides in residential homes. … Results show … measurable levels of insecticides  http://www.ncbi.nlm.nih.gov/pubmed/19603637 Daniel M. Stout II *†, Karen D. Bradham †, Peter P. Egeghy †, Paul A. Jones †, Carry W. Croghan †, Peter A. Ashley ‡, Eugene Pinzer ‡, Warren Friedman ‡, Marielle C. Brinkman §, Marcia G. Nishioka § and David C. Cox   National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Office of Healthy Homes and Lead Hazard Control, U.S. Department of Housing and Urban Development, 451 seventh Street, SW, Washington, D.C. 20410, Battelle Memorial Institute, 505 King Avenue, Columbus, Ohio 43201, Quantech, 2020 N 14th St, Suite 41,0 Arlington, Virginia 22201 Environ. Sci. Technol., 2009, 43 (12), pp 4294–4300 DOI: 10.1021/es8030243 Publication Date (Web): May 6, 2009 Copyright © 2009 American Chemical Society 

4. Banned: Flea collars are pulled of the shelves in France, citing danger to pets and children  April 28, 2012  Mollie Morrissette  SOURCE: Sciences et Avenir http://www.poisonedpets.com/flea-collars-are-pulled-of-the-shelves-in-france-citing-danger-to-pets-and-children/ 

5. Fipronil Levels Indoors Fipronil is a potent insecticide … residences with a dog …were among the five residences with elevated fipronil concentrations.  http://www.cdpr.ca.gov/docs/dept/comguide/effects_excerpt.pdf  LisaJo Melnyk †*, Margie Z. Byron ‡, G. Gordon Brown §, C. Andrew Clayton , and Larry C. Michael §  † U.S. Environmental Protection Agency Office of Research and Development National Exposure Research Laboratory  26 West Martin Luther King Drive Cincinnati, Ohio 45268, United States ‡ Rho, Inc. 6330 Quadrangle Drive Suite 500 Chapel Hill, North Carolina 27517, United States § RTI International 3040 Cornwallis Road Research Triangle Park, North Carolina 27709, United States Environ. Sci. Technol., 2011, 45 (10), pp 4594–4601 DOI: 10.1021/es104190k Publication Date (Web): April 25, 2011 Copyright © 2011 American Chemical Society 

6.  Spot On: Increase in incidents associated with spot-on EPA is concerned about the increase in incidents associated with spot-on flea and tick products. http://www.wptv.com/dpp/news/national/pet-owners-warn-of-danger-with-flea-and-tick-medication-ews-orginal- 201005191274285865081 Peter T. Meinke * Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 2000, RY800-B101, Rahway, New Jersey 07065-0900  J. Med. Chem., 2001, 44 (5), pp 641–659 DOI: 10.1021/jm990564h Publication Date (Web): February 6, 2001 Copyright © 2001 American Chemical Society 

7. Natural Resources Defense Council files lawsuit NRDC found high levels of … carcinogenic neurotoxin … on pet fur after use of ordinary flea collars. http://www.nrdc.org/search.asp?cof=FORID%3A11&ie=UTF-8&q=propoxur&sa.x=0&sa.y=0&cx=001024953138106184952%3Alevppyfplwy&hq=-inurl%3Ahttps&t=iframe http://www.nrdc.org/media/2009/090423a.asp Lawsuit Seeks to Protect Consumers from Toxic Pet Products  New NRDC Analysis Reveals Flea Collars Create Toxic Chemical Residues on Pet Fur that Threaten Human Health SAN FRANCISCO (April 23, 2009) 

8.  Statistically Speaking: Number of Pet Deaths from … Flea & Tick Collars and Spot-on Products http://www2.epa.gov/pets/epa-evaluation-pet-spot-products-analysis-and-plans-reducing-harmful-effects Pesticides: Health and Safety 2008 Reported Incidents for Flea and Tick Products for Dogs and Cats Data obtained from the U.S. Environmental Protection Agency on 4/1/2010 

9. Chemical Culprits: Flea-Control Chemicals http://livinggreenmag.com/2012/08/15/home-garden/a-natural-approach-to-flea-and-tick-control-keeps-toxins-away-from-pets- and-children/ A Natural Approach to Flea and Tick Control Keeps Toxins Away from Pets and Children Living Green Magazine Richard Kujawski, Managing Editor 

10. Pet Shampoos Containing Insecticides Linked to Autism Study … shows that pet shampoos containing insecticides may trigger autism spectrum disorders http://www.beyondpesticides.org/dailynewsblog/?p=356 Pet Shampoos Containing Insecticides Linked to Autism (Beyond Pesticides, May 27, 2008) 

11. Fipronil: A Multitude of Concerning Health Effects http://npic.orst.edu/factsheets/fipronil.pdf NPIC Technical Fact Sheets Oregon State University, 310 Weniger Hall, Corvallis, OR 97331-6502